To formulate Helicters isora Linn fruit extract in to a gel and evaluate the antimicrobial activity. The aqueous extract of dried fruit of Helicters isora Linn was subjected to antimicrobial activity. The aqueous extract of dried fruits of Helicters isora Linn were subjected to preliminary phytochemical evaluations and antibacterial activity using cup plate method in concentration of 1% and 2%. The bacterial cultures selected for testing’s included S. typhi and S. aureus. The aqueous extract showed inhibition in growth of bacterial culture and slightly better activity against S. aureus as compaired to S. typhi. The different gel formulations of aqueous extract of Helicteres isora Linn were prepared by using polymers carbopol 934 and HPMC by varying their concentration. These formulations were evaluated for physical parameters, drug content, pH, viscosity, extrudability, spreadability, in-vitro drug release and stability study. The formulation with carbopol 934 was found to be more promising as it shows better physicochemical characteristics and drug release compared to other formulations.
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